GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9527 | 1 | rs4919690 | chr10:104616500 | AS3MT | chr10:104613967-104661653:+ | 0.39 | 4.43 | 2.57E-5 | Arsenic metabolism |
| THYM | cis | rs2028299 | 1 | rs4932143 | chr15:90372067 | AP3S2 | chr15:90373832-90456222:- | -0.42 | -4.71 | 8.38E-6 | Type 2 diabetes |
| THYM | cis | rs2028299 | 1 | rs4932148 | chr15:90394356 | AP3S2 | chr15:90373832-90456222:- | -0.37 | -4.18 | 6.51E-5 | Type 2 diabetes |
| THYM | cis | rs494003 | 1 | rs494003 | chr11:65542298 | SNX32 | chr11:65601410-65621170:+ | 0.41 | 4.48 | 2.05E-5 | Systemic lupus erythematosus |
| THYM | cis | rs7552404 | 1 | rs4949674 | chr1:76213715 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.21E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs7552404 | 1 | rs4949874 | chr1:76161889 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.21E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs7552404 | 1 | rs4949876 | chr1:76173377 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.21E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs951366 | 1 | rs4951261 | chr1:205717823 | PM20D1 | chr1:205797154-205819245:- | 0.53 | 4.83 | 5.15E-6 | Menarche (age at onset) |
| THYM | cis | rs10935120 | 1 | rs4955485 | chr3:134295843 | ANAPC13 | chr3:134196547-134204865:- | 0.55 | 7.52 | 3.08E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs4955485 | chr3:134295843 | CEP63 | chr3:134204575-134293852:+ | 0.42 | 6.29 | 9.47E-9 | Height |
| THYM | cis | rs10935120 | 1 | rs4955555 | chr3:134286427 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 8.01 | 2.88E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs4955555 | chr3:134286427 | CEP63 | chr3:134204575-134293852:+ | 0.41 | 6.04 | 2.93E-8 | Height |
| THYM | cis | rs2251844 | 1 | rs496584 | chr15:43831923 | ADAL | chr15:43622872-43646094:+ | -0.61 | -5.06 | 2.08E-6 | Tumor biomarkers |
| THYM | cis | rs9815354 | 1 | rs4973991 | chr3:41927273 | ULK4 | chr3:41288091-42003660:- | -1 | -11.02 | 1.12E-18 | Diastolic blood pressure |
| THYM | cis | rs10935120 | 1 | rs4974483 | chr3:134219001 | ANAPC13 | chr3:134196547-134204865:- | 0.56 | 7.61 | 1.94E-11 | Height |